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KMID : 0357119870090010059
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Korean Journal of Immunology
1987 Volume.9 No. 1 p.59 ~ p.66
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The Neutrophil Chemotaxis in Systemic Rheumatic Disorders
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박석영/Park, Suk Young
신호균/백상홍/김호연/이경식/Shin, Ho Kyun/Baek, Sang Hong/Lee, Kyung Sik/Kim, Dong Jip
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Abstract
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Neutrophil chemotax is to N-tormylmethionylleucylphenylalanine was studied in 47 subjects with systemic rheumatic disorders by means of micropore filter asssy(multiwell microchemotactic chamber method).
The following results were obtained.
1. The chemotactic activity in systemic lupus erythematosus patients(Total 13) was significantly higher in active stage(rnean ±S.D., 141.7±38.2) than that in remission stage(mean±S.D., 89.1±21.1) (P< 0.05).
2. The chemctactic activity in rheumatoid arthritis patients(total 13) was increased(mean±S.D., 148.3 ±40.0). There was no significant difference in chemotactic activities among 3 different Riche score groups(mean±S.D., less than 5, 5-9, more than 10; 127.6±22.1, 177.5±61. 4, 141.0± 16.4, respec tively)(P < 0.05).
3. The chemotactic activity in ankylosing spondylitis patients(total 3) was increased(mean±S.D.,114.7 ± 9.5).
4. The chemotactic activity in Behcet´s disease patients(total 15) was increased(mean±S.D., 140.0±-44.3). There was no significant difference in chemotactic activities among HI,A-Bs, antigen positive or negative, active or inactive, and complete or incomplete form groups(P <0.05).
These results suggest that the increased chemotactic activity of neutrophil to N-formylmethionylleucylalanine in systemic rheumatic disorders, whose mechanism is not yet known, may reflect the ongoing inflamatory process of the diseases itself as a activity indicator or appear to be related to their pathogenitic mechanisms.
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